InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AGAP2

Summary

InnateDB Gene

IDBG-634920.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGAP2

Gene Name

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007156

Encoded Proteins

IDBP-686714

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135439:
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:56051446-56062903

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009418

ENSBTAP00000009418

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032312	regulation of ARF GTPase activity
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046427	positive regulation of JAK-STAT cascade
GO:0060749	mammary gland alveolus development