InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lmo2

Summary

InnateDB Gene

IDBG-194172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmo2

Gene Name

LIM domain only 2

Synonyms

Rbtn-2; Rbtn2; Rhom-2; Ttg2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032698

Encoded Proteins

IDBP-258753

LIM domain only 2

IDBP-258755

LIM domain only 2

IDBP-258757

LIM domain only 2

IDBP-536636

LIM domain only 2

IDBP-533283

LIM domain only 2

IDBP-541847

LIM domain only 2

IDBP-625709

LIM domain only 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135363:
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:103957986-103981878

Strand

Forward strand

Band

Transcripts

ENSMUST00000111143	ENSMUSP00000106773
ENSMUST00000111140	ENSMUSP00000106770
ENSMUST00000111139	ENSMUSP00000106769
ENSMUST00000156813	ENSMUSP00000122369
ENSMUST00000123437	ENSMUSP00000117703
ENSMUST00000138815	ENSMUSP00000121927
ENSMUST00000133210
ENSMUST00000170926	ENSMUSP00000128317

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	15 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043425	bHLH transcription factor binding
GO:0048037	cofactor binding
GO:0070888	E-box binding

Biological Process

GO:0035162	embryonic hemopoiesis
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000135363

View Gene Order

ENSBTAG00000006951

Not yet available

Cross-References

SwissProt

TrEMBL

A2BHP2 A2BHP3 A2BHP4 Q544Z2

UniProt Splice Variant

Entrez Gene

16909

UniGene

Mm.29266 Mm.401119

RefSeq

NM_008505 NM_001142335 NM_001142336 NM_001142337 XM_006498820 XM_006498821

OMIM

CCDS

CCDS16482 CCDS50651 CCDS50652

HPRD

IMGT

MGI ID

MGI:102811

MGI Symbol

Lmo2

EMBL

AK013416 BC057880 BX640578 M64360

GenPept

AAA40054 AAH57880 BAB28844

RNA Seq Atlas

16909