Version 5.4
Bos taurus Gene: LMO2
Summary
InnateDB Gene IDBG-636445.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMO2
Gene Name Rhombotin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006951
Encoded Proteins
IDBP-688363
Rhombotin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135363:
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:65394511-65407118
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009126 ENSBTAP00000009126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043425 bHLH transcription factor binding
GO:0046872 metal ion binding
GO:0048037 cofactor binding
GO:0070888 E-box binding
Biological Process
GO:0035162 embryonic hemopoiesis
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097067 cellular response to thyroid hormone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135363
View Gene Order
ENSMUSG00000032698
View Gene Order
Cross-References
SwissProt Q1LZ94
TrEMBL
UniProt Splice Variant
Entrez Gene 614876
UniGene Bt.17081
RefSeq NM_001076352
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116134
GenPept AAI16135
RNA Seq Atlas 614876

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca