Version 5.4
Mus musculus Gene: B4galnt1
Summary
InnateDB Gene IDBG-194245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B4galnt1
Gene Name beta-1,4-N-acetyl-galactosaminyl transferase 1
Synonyms 4933429D13Rik; Gal-NAc-T; Galgt1; GalNAc-T; GalNAcT; Ggm-2; Ggm2
Species Mus musculus
Ensembl Gene ENSMUSG00000006731
Encoded Proteins
IDBP-194247
beta-1,4-N-acetyl-galactosaminyl transferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135454:
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:127165156-127172340
Strand Forward strand
Band D3
Transcripts
ENSMUST00000006914 ENSMUSP00000006914
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
GO:0008376 acetylgalactosaminyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0006687 glycosphingolipid metabolic process
GO:0007283 spermatogenesis
GO:0019915 lipid storage
GO:0030259 lipid glycosylation
Cellular Component
GO:0005886 plasma membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135454
View Gene Order
ENSBTAG00000004494
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00604
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00604
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.386762 Mm.490085
RefSeq NM_008080 NM_027739 XM_006513217 XM_006513219
OMIM
CCDS CCDS24230
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca