Version 5.4
Mus musculus Gene: Cdkn1b
Summary
InnateDB Gene IDBG-194318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdkn1b
Gene Name cyclin-dependent kinase inhibitor 1B
Synonyms AA408329; AI843786; Kip1; p27; p27Kip1
Species Mus musculus
Ensembl Gene ENSMUSG00000003031
Encoded Proteins
IDBP-194320
cyclin-dependent kinase inhibitor 1B
IDBP-194322
cyclin-dependent kinase inhibitor 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111276:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:134920401-134925513
Strand Forward strand
Band G1
Transcripts
ENSMUST00000067327 ENSMUSP00000065832
ENSMUST00000003115 ENSMUSP00000003115
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903 protein phosphatase binding
GO:0030544 Hsp70 protein binding
GO:0032403 protein complex binding
GO:0051087 chaperone binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001666 response to hypoxia
GO:0006813 potassium ion transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007050 cell cycle arrest
GO:0007605 sensory perception of sound
GO:0008219 cell death
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009749 response to glucose
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0030308 negative regulation of cell growth
GO:0031116 positive regulation of microtubule polymerization
GO:0032355 response to estradiol
GO:0033673 negative regulation of kinase activity
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0046686 response to cadmium ion
GO:0048102 autophagic cell death
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051271 negative regulation of cellular component movement
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236 cellular response to antibiotic
GO:0071285 cellular response to lithium ion
GO:0071407 cellular response to organic cyclic compound
GO:0071850 mitotic cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111276
View Gene Order
ENSBTAG00000018254
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_205300
PI3K/AKT activation pathway
REACT_260005
G1 Phase pathway
REACT_189085
Disease pathway
REACT_258062
Synthesis of DNA pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188957
Cellular responses to stress pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_257943
p53-Dependent G1 DNA Damage Response pathway
REACT_254524
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_230745
Immune System pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_255479
Regulation of DNA replication pathway
REACT_188820
Cellular Senescence pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_242976
Signaling by EGFR pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_246312
G1/S DNA Damage Checkpoints pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_220918
AKT phosphorylates targets in the cytosol pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_220647
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_253623
S Phase pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04012
ErbB signaling pathway pathway
mmu04110
Cell cycle pathway
mmu05222
Small cell lung cancer pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_12564
AKT phosphorylates targets in the cytosol pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_383
DNA Replication pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_899
S Phase pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_1783
G1/S Transition pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_829
Regulation of DNA replication pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04110
Cell cycle pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
rb_1pathway
Regulation of retinoblastoma protein
avb3_integrin_pathway
Integrins in angiogenesis
myc_represspathway
Validated targets of C-MYC transcriptional repression
foxopathway
FoxO family signaling
hes_heypathway
Notch-mediated HES/HEY network
rhoa_reg_pathway
Regulation of RhoA activity
ap1_pathway
AP-1 transcription factor network
cmyb_pathway
C-MYB transcription factor network
e2f_pathway
E2F transcription factor network
rhoa_pathway
RhoA signaling pathway
hnf3apathway
FOXA1 transcription factor network
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt P46414
TrEMBL
UniProt Splice Variant
Entrez Gene 12576
UniGene Mm.2958 Mm.471167 Mm.471811
RefSeq NM_009875 XM_006505466
OMIM
CCDS CCDS20642
HPRD
IMGT
MGI ID MGI:104565
MGI Symbol Cdkn1b
EMBL AC122193 AK046676 AK047669 AK050240 BC014296 U09968 U10440
GenPept AAA20235 AAA21149 AAH14296 BAC32833 BAC33119 BAC34141
RNA Seq Atlas 12576

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca