InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkn1b

Summary

InnateDB Protein

IDBP-194320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn1b

Protein Name

cyclin-dependent kinase inhibitor 1B

Synonyms

AA408329; AI843786; Kip1; p27; p27Kip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065832

InnateDB Gene

IDBG-194318 (Cdkn1b)

Protein Structure

UniProt Annotation

Function

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of cyclin D-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269PubMed:12093740, ECO:0000269PubMed:15528185, ECO:0000269PubMed:20228253, ECO:0000269PubMed:9399644}.

Subcellular Localization

Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-197, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser- 10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 (By similarity). Colocalizes at the endosome with SNX6; this leads to lysosomal degradation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	82 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903	protein phosphatase binding
GO:0030544	Hsp70 protein binding
GO:0032403	protein complex binding
GO:0051087	chaperone binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001666	response to hypoxia
GO:0006813	potassium ion transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007050	cell cycle arrest
GO:0007605	sensory perception of sound
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009749	response to glucose
GO:0010942	positive regulation of cell death
GO:0030308	negative regulation of cell growth
GO:0031116	positive regulation of microtubule polymerization
GO:0032355	response to estradiol
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043200	response to amino acid
GO:0043434	response to peptide hormone
GO:0045732	positive regulation of protein catabolic process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0046686	response to cadmium ion
GO:0048102	autophagic cell death
GO:0048839	inner ear development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051271	negative regulation of cellular component movement
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236	cellular response to antibiotic
GO:0071285	cellular response to lithium ion
GO:0071407	cellular response to organic cyclic compound
GO:0071850	mitotic cell cycle arrest