Version 5.4
| Mus musculus Gene: Cxcl16 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-194380.6 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | Cxcl16 | ||||||||||||||||
| Gene Name | chemokine (C-X-C motif) ligand 16 | ||||||||||||||||
| Synonyms | 0910001K24Rik; AV290116; b2b498Clo; BB024863; CXCL16v1; CXCL16v2; SR-PSOX; Zmynd15 | ||||||||||||||||
| Species | Mus musculus | ||||||||||||||||
| Ensembl Gene | ENSMUSG00000018920 | ||||||||||||||||
| Encoded Proteins |
chemokine (C-X-C motif) ligand 16
chemokine (C-X-C motif) ligand 16
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| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| InnateDB Annotation | |||||||||||||||||
| Summary |
Cxcl16 is a chemoattractant in cerebrospinal fluid in early pneumococcal meningitis where Cxcl16 was found to be upregulated in RAW264.7 macrophages (but not in neutrophils and endothelial cells) upon pneumococcal stimulation. Cxcl16 upregulation in vivo was dependent on Toll-like receptor (TLR) 2/TLR4 and MyD88 signaling.
Cxcl16-Cxcr6 crosstalk coordinates the intestinal topography of Il22 secretion required for mucosal defence against Citrobacter rodentium infection.
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| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161921:
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 11:70453983-70459984 | ||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||
| Band | B3 | ||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
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| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
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| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | |||||||||||||||||
| UniGene | Mm.425692 | ||||||||||||||||
| RefSeq | NM_023158 | ||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | CCDS24948 | ||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| MGI ID | |||||||||||||||||
| MGI Symbol | |||||||||||||||||
| EMBL | |||||||||||||||||
| GenPept | |||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||