InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcl16

Summary

InnateDB Protein

IDBP-194382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl16

Protein Name

chemokine (C-X-C motif) ligand 16

Synonyms

0910001K24Rik; AV290116; b2b498Clo; BB024863; CXCL16v1; CXCL16v2; SR-PSOX; Zmynd15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019064

InnateDB Gene

IDBG-194380 (Cxcl16)

Protein Structure

UniProt Annotation

Function

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. {ECO:0000269PubMed:11060282}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Not detected in purified B- and T-cells. {ECO:0000269PubMed:11017100, ECO:0000269PubMed:20675388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0008009	chemokine activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0034097	response to cytokine
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor
GO:0045087	innate immune response (InnateDB)
GO:0048247	lymphocyte chemotaxis