InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cit

Summary

InnateDB Gene

IDBG-194406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cit

Gene Name

citron

Synonyms

C030025P15Rik; Cit-k; CRIK; CRIK-SK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029516

Encoded Proteins

IDBP-194408

citron

IDBP-194410

citron

IDBP-256877

citron

IDBP-538465

citron

IDBP-542215

citron

IDBP-725006

IDBP-536869

citron

IDBP-725113

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122966:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:115845278-116008947

Strand

Forward strand

Band

Transcripts

ENSMUST00000102560	ENSMUSP00000099620
ENSMUST00000051704	ENSMUSP00000062049
ENSMUST00000112008	ENSMUSP00000107639
ENSMUST00000147330
ENSMUST00000137952	ENSMUSP00000122745
ENSMUST00000148245	ENSMUSP00000119769
ENSMUST00000146387
ENSMUST00000153407
ENSMUST00000127976	ENSMUSP00000135649
ENSMUST00000128702
ENSMUST00000141101	ENSMUSP00000115802
ENSMUST00000145363
ENSMUST00000147479
ENSMUST00000139881
ENSMUST00000122877
ENSMUST00000136780
ENSMUST00000123736	ENSMUSP00000134875
ENSMUST00000134609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0030165	PDZ domain binding
GO:0046872	metal ion binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000910	cytokinesis
GO:0006468	protein phosphorylation
GO:0007030	Golgi organization
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0008064	regulation of actin polymerization or depolymerization
GO:0016358	dendrite development
GO:0035556	intracellular signal transduction
GO:0045665	negative regulation of neuron differentiation
GO:0050774	negative regulation of dendrite morphogenesis
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005773	vacuole
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0031985	Golgi cisterna
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000122966

View Gene Order

ENSBTAG00000008963

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

rhoa_pathway

RhoA signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.426282 Mm.458239 Mm.474759 Mm.8321

RefSeq

NM_007708 XM_006530140 XM_006530141 XM_006530143 XM_006530151

OMIM

CCDS

CCDS19597

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas