InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CIT

Summary

InnateDB Gene

IDBG-60008.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIT

Gene Name

citron (rho-interacting, serine/threonine kinase 21)

Synonyms

CRIK; STK21

Species

Homo sapiens

Ensembl Gene

ENSG00000122966

Encoded Proteins

IDBP-60010

citron (rho-interacting, serine/threonine kinase 21)

IDBP-245485

citron (rho-interacting, serine/threonine kinase 21)

IDBP-245487

citron (rho-interacting, serine/threonine kinase 21)

IDBP-584757

citron (rho-interacting, serine/threonine kinase 21)

IDBP-589705

citron (rho-interacting, serine/threonine kinase 21)

IDBP-809029

citron rho-interacting serine/threonine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:119685790-119877291

Strand

Reverse strand

Band

q24.23

Transcripts

ENST00000261833	ENSP00000261833
ENST00000392521	ENSP00000376306
ENST00000392520	ENSP00000376305
ENST00000469414
ENST00000488203
ENST00000545913
ENST00000537607
ENST00000544872
ENST00000538073
ENST00000543324
ENST00000544800
ENST00000543239
ENST00000536008
ENST00000544588
ENST00000536325	ENSP00000443199
ENST00000546026	ENSP00000446105
ENST00000541841
ENST00000539413
ENST00000612548	ENSP00000482318

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0017124	SH3 domain binding
GO:0030165	PDZ domain binding
GO:0046872	metal ion binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000910	cytokinesis
GO:0006468	protein phosphorylation
GO:0007030	Golgi organization
GO:0007067	mitotic nuclear division
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0008064	regulation of actin polymerization or depolymerization
GO:0016358	dendrite development
GO:0035556	intracellular signal transduction
GO:0048699	generation of neurons
GO:0050774	negative regulation of dendrite morphogenesis
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005773	vacuole
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0031985	Golgi cisterna
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029516

View Gene Order

ENSBTAG00000008963

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

rhoa_pathway

RhoA signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.119594 Hs.595215 Hs.673192 Hs.707600

RefSeq

NM_001206999 NM_007174 XM_005253829

HUGO

OMIM

CCDS

CCDS55891 CCDS9192

HPRD

09289

IMGT

EMBL

GenPept

RNA Seq Atlas