InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Efna5

Summary

InnateDB Gene

IDBG-194549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efna5

Gene Name

ephrin A5

Synonyms

AL-1; AV158822; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000048915

Encoded Proteins

IDBP-194551

ephrin A5

IDBP-194553

ephrin A5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184349:
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:62604184-62881317

Strand

Reverse strand

Band

E1.1

Transcripts

ENSMUST00000076840	ENSMUSP00000076115
ENSMUST00000078839	ENSMUSP00000077883

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0045499	chemorepellent activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007411	axon guidance
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0051893	regulation of focal adhesion assembly
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070507	regulation of microtubule cytoskeleton organization

Cellular Component

GO:0005886	plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0031362	anchored component of external side of plasma membrane
GO:0046658	anchored component of plasma membrane