InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fgr

Summary

InnateDB Gene

IDBG-194595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgr

Gene Name

Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028874

Encoded Proteins

IDBP-194597

Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog

IDBP-627771

Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000000938:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:132974095-133001910

Strand

Forward strand

Band

D2.3

Transcripts

ENSMUST00000030693	ENSMUSP00000030693
ENSMUST00000124451
ENSMUST00000138179
ENSMUST00000171223	ENSMUSP00000128411

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0034987	immunoglobulin receptor binding
GO:0034988	Fc-gamma receptor I complex binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007229	integrin-mediated signaling pathway
GO:0008360	regulation of cell shape
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030335	positive regulation of cell migration
GO:0032956	regulation of actin cytoskeleton organization
GO:0043306	positive regulation of mast cell degranulation
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response
GO:0045859	regulation of protein kinase activity
GO:0046777	protein autophosphorylation
GO:0050715	positive regulation of cytokine secretion
GO:0050764	regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome