Version 5.4
Mus musculus Gene: Prc1
Summary
InnateDB Gene IDBG-194901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prc1
Gene Name protein regulator of cytokinesis 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038943
Encoded Proteins
IDBP-194905
protein regulator of cytokinesis 1
IDBP-627815
protein regulator of cytokinesis 1
IDBP-627820
protein regulator of cytokinesis 1
IDBP-627821
protein regulator of cytokinesis 1
IDBP-627822
protein regulator of cytokinesis 1
IDBP-627823
protein regulator of cytokinesis 1
IDBP-627824
protein regulator of cytokinesis 1
IDBP-627825
protein regulator of cytokinesis 1
IDBP-627826
protein regulator of cytokinesis 1
IDBP-627827
protein regulator of cytokinesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198901:
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:80294450-80316259
Strand Forward strand
Band D2
Transcripts
ENSMUST00000047558 ENSMUSP00000043379
ENSMUST00000163812 ENSMUSP00000129675
ENSMUST00000172911
ENSMUST00000174199 ENSMUSP00000133295
ENSMUST00000173914
ENSMUST00000173824 ENSMUSP00000133910
ENSMUST00000174172 ENSMUSP00000133387
ENSMUST00000174254
ENSMUST00000173170 ENSMUSP00000133817
ENSMUST00000174051 ENSMUSP00000134262
ENSMUST00000172781 ENSMUSP00000133618
ENSMUST00000174111 ENSMUSP00000134282
ENSMUST00000174599 ENSMUSP00000134548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000910 cytokinesis
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198901
View Gene Order
ENSBTAG00000018643
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL G3UY19
UniProt Splice Variant
Entrez Gene 233406
UniGene Mm.227274
RefSeq NM_001285998 NM_001285997 NM_145150 XM_006540856
OMIM
CCDS CCDS71986 CCDS39998 CCDS71985
HPRD
IMGT
MGI ID MGI:1858961
MGI Symbol Prc1
EMBL AC109232 AC136740 CH466543
GenPept EDL07013
RNA Seq Atlas 233406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca