Version 5.4
Bos taurus Gene: BT.20428
Summary
InnateDB Gene IDBG-629366.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.20428
Gene Name protein regulator of cytokinesis 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018643
Encoded Proteins
IDBP-680782
protein regulator of cytokinesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198901:
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:22100872-22122836
Strand Forward strand
Band
Transcripts
ENSBTAT00000024808 ENSBTAP00000024808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000910 cytokinesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198901
View Gene Order
ENSMUSG00000038943
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL F1MRT3
UniProt Splice Variant
Entrez Gene 767818
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052162 DAAA02052163
GenPept
RNA Seq Atlas 767818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca