InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PAIP1

Summary

InnateDB Gene

IDBG-19493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAIP1

Gene Name

poly(A) binding protein interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000172239

Encoded Proteins

IDBP-19497

poly(A) binding protein interacting protein 1

IDBP-19499

poly(A) binding protein interacting protein 1

IDBP-366500

poly(A) binding protein interacting protein 1

IDBP-475516

poly(A) binding protein interacting protein 1

IDBP-478953

poly(A) binding protein interacting protein 1

IDBP-476813

poly(A) binding protein interacting protein 1

IDBP-483800

poly(A) binding protein interacting protein 1

IDBP-477109

poly(A) binding protein interacting protein 1

IDBP-473432

poly(A) binding protein interacting protein 1

IDBP-473979

poly(A) binding protein interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:43526267-43557758

Strand

Reverse strand

Band

p12

Transcripts

ENST00000338972	ENSP00000339622
ENST00000306846	ENSP00000302768
ENST00000436644	ENSP00000387729
ENST00000514816	ENSP00000426089
ENST00000514514	ENSP00000425084
ENST00000504639	ENSP00000422084
ENST00000511321	ENSP00000425675
ENST00000508537	ENSP00000425736
ENST00000504075	ENSP00000427410
ENST00000515338	ENSP00000425406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0008494	translation activator activity

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006413	translational initiation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0045727	positive regulation of translation
GO:0048255	mRNA stabilization

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025451

View Gene Order

ENSBTAG00000020376

Not yet available

Pathways

NETPATH

REACTOME

REACT_20514

Deadenylation of mRNA pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.482038 Hs.596048 Hs.641972 Hs.649212

RefSeq

NM_006451 NM_182789 NM_183323 XM_005248230

HUGO

OMIM

CCDS

CCDS3947 CCDS3948 CCDS47204

HPRD

05539

IMGT

EMBL

GenPept

RNA Seq Atlas