InnateDB Protein
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IDBP-19499.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PAIP1
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Protein Name
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poly(A) binding protein interacting protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302768
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InnateDB Gene
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IDBG-19493 (PAIP1)
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Protein Structure
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Function |
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. {ECO:0000269PubMed:11051545, ECO:0000269PubMed:9548260}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003890
MIF4G-like, type 3
IPR009818
Ataxin-2, C-terminal
IPR016024
Armadillo-type fold
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PFAM |
PF02854
PF07145
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PRINTS |
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PIRSF |
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SMART |
SM00543
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H074
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PhosphoSite |
PhosphoSite-Q9H074
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TrEMBL |
D6RJF2
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UniProt Splice Variant |
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Entrez Gene |
10605
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UniGene |
Hs.649212
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RefSeq |
NP_006442
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HUGO |
HGNC:16945
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OMIM |
605184
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CCDS |
CCDS3947
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HPRD |
05539
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IMGT |
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EMBL |
AC114956
AF013758
AL136920
BC005295
BC015937
DB089732
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GenPept |
AAC39697
AAH05295
AAH15937
CAB66854
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