InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxw8

Summary

InnateDB Gene

IDBG-195076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxw8

Gene Name

F-box and WD-40 domain protein 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032867

Encoded Proteins

IDBP-195078

F-box and WD-40 domain protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174989:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:118064981-118155458

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049474

ENSMUSP00000047012

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007030	Golgi organization
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0050775	positive regulation of dendrite morphogenesis
GO:0060712	spongiotrophoblast layer development
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005794	Golgi apparatus
GO:0019005	SCF ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm
GO:1990393	3M complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000174989

View Gene Order

ENSBTAG00000036183

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

Q8BIA4

TrEMBL

UniProt Splice Variant

Entrez Gene

231672

UniGene

Mm.221769

RefSeq

NM_172721

OMIM

CCDS

CCDS19609

HPRD

IMGT

MGI ID

MGI:1923041

MGI Symbol

Fbxw8

EMBL

AK034447 AK047695 AK047756 AK053794 BC009095 BC024091

GenPept

AAH09095 AAH24091 BAC28712 BAC33128 BAC33147 BAC35527

RNA Seq Atlas

231672