InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXW8

Summary

InnateDB Gene

IDBG-59327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW8

Gene Name

F-box and WD repeat domain containing 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000174989

Encoded Proteins

IDBP-59329

F-box and WD repeat domain containing 8

IDBP-383802

F-box and WD repeat domain containing 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:116910956-117031148

Strand

Forward strand

Band

q24.22

Transcripts

ENST00000309909	ENSP00000310686
ENST00000455858	ENSP00000389144
ENST00000551773

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0007030	Golgi organization
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0050775	positive regulation of dendrite morphogenesis
GO:0060712	spongiotrophoblast layer development
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005794	Golgi apparatus
GO:0019005	SCF ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm
GO:1990393	3M complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032867

View Gene Order

ENSBTAG00000036183

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.696428

RefSeq

NM_012174 NM_153348 XM_005253866 XM_005253868

HUGO

OMIM

CCDS

CCDS44988 CCDS9182

HPRD

16427

IMGT

EMBL

GenPept

RNA Seq Atlas