InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cenpe

Summary

InnateDB Gene

IDBG-195146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cenpe

Gene Name

centromere protein E

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045328

Encoded Proteins

IDBP-195148

centromere protein E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138778:
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008]
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:135212563-135273540

Strand

Forward strand

Band

Transcripts

ENSMUST00000062893

ENSMUSP00000057938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0043515	kinetochore binding

Biological Process

GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0045860	positive regulation of protein kinase activity

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000779	condensed chromosome, centromeric region
GO:0000940	condensed chromosome outer kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane