InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fes

Summary

InnateDB Gene

IDBG-195240.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fes

Gene Name

feline sarcoma oncogene

Synonyms

AI586313; BB137047; c-fes; FPS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000053158

Encoded Proteins

IDBP-195244

feline sarcoma oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182511:
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:80377758-80387946

Strand

Reverse strand

Band

Transcripts

ENSMUST00000080932

ENSMUSP00000079733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0034987	immunoglobulin receptor binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006468	protein phosphorylation
GO:0008360	regulation of cell shape
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030155	regulation of cell adhesion
GO:0031116	positive regulation of microtubule polymerization
GO:0042127	regulation of cell proliferation
GO:0043304	regulation of mast cell degranulation
GO:0045595	regulation of cell differentiation
GO:0045639	positive regulation of myeloid cell differentiation
GO:0046777	protein autophosphorylation
GO:2000145	regulation of cell motility
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0015630	microtubule cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031410	cytoplasmic vesicle