InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FES

Summary

InnateDB Gene

IDBG-629472.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FES

Gene Name

tyrosine-protein kinase Fes/Fps

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002941

Encoded Proteins

IDBP-680876

tyrosine-protein kinase Fes/Fps

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182511:
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:22192640-22204117

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003828

ENSBTAP00000003828

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0034987	immunoglobulin receptor binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006468	protein phosphorylation
GO:0008360	regulation of cell shape
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030155	regulation of cell adhesion
GO:0031116	positive regulation of microtubule polymerization
GO:0042127	regulation of cell proliferation
GO:0043304	regulation of mast cell degranulation
GO:0045595	regulation of cell differentiation
GO:0045639	positive regulation of myeloid cell differentiation
GO:0046777	protein autophosphorylation
GO:2000145	regulation of cell motility
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0015630	microtubule cytoskeleton
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031410	cytoplasmic vesicle