InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Shmt2

Summary

InnateDB Gene

IDBG-195290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shmt2

Gene Name

serine hydroxymethyltransferase 2 (mitochondrial)

Synonyms

2700043D08Rik; AA408223; AA986903

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025403

Encoded Proteins

IDBP-195292

serine hydroxymethyltransferase 2 (mitochondrial)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182199:
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127517123-127522444

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026470

ENSMUSP00000026470

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004372	glycine hydroxymethyltransferase activity
GO:0008732	L-allo-threonine aldolase activity
GO:0016597	amino acid binding
GO:0030170	pyridoxal phosphate binding
GO:0042802	identical protein binding

Biological Process

GO:0006544	glycine metabolic process
GO:0006545	glycine biosynthetic process
GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0019264	glycine biosynthetic process from serine
GO:0035999	tetrahydrofolate interconversion
GO:0051289	protein homotetramerization

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0015630	microtubule cytoskeleton
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000182199

View Gene Order

ENSBTAG00000031500

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00260

Glycine, serine and threonine metabolism pathway

mmu00460

Cyanoamino acid metabolism pathway

mmu00670

One carbon pool by folate pathway

mmu00630

Glyoxylate and dicarboxylate metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00670

One carbon pool by folate pathway

hsa00460

Cyanoamino acid metabolism pathway

hsa00260

Glycine, serine and threonine metabolism pathway

hsa00630

Glyoxylate and dicarboxylate metabolism pathway

INOH

INOH website

Folate metabolism pathway

INOH website

Glycine Serine metabolism pathway

INOH website

Lysine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

Q3TFD0 Q9CZN7

UniProt Splice Variant

Entrez Gene

108037

UniGene

Mm.29890 Mm.452389

RefSeq

NM_001252316 NM_028230

OMIM

CCDS

CCDS24244

HPRD

IMGT

MGI ID

MGI:1277989

MGI Symbol

Shmt2

EMBL

AC167719 AK012355 AK037339 AK051207 AK162421 AK169192

GenPept

BAB28184 BAC29790 BAC34556 BAE36907 BAE40968

RNA Seq Atlas

108037