Version 5.4
Homo sapiens Gene: SHMT2
Summary
InnateDB Gene IDBG-42369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHMT2
Gene Name serine hydroxymethyltransferase 2 (mitochondrial)
Synonyms GLYA; HEL-S-51e; SHMT
Species Homo sapiens
Ensembl Gene ENSG00000182199
Encoded Proteins
IDBP-42371
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-378499
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-378500
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-597838
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-597539
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-591321
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-600404
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-602231
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-588505
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-587691
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-599404
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-596398
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-597026
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-595283
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-597001
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-595928
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-591209
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-583393
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-587146
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-590062
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-599166
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-595752
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-590240
serine hydroxymethyltransferase 2 (mitochondrial)
IDBP-593437
serine hydroxymethyltransferase 2 (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57229327-57234935
Strand Forward strand
Band q13.3
Transcripts
ENST00000328923 ENSP00000333667
ENST00000449049 ENSP00000413770
ENST00000414700 ENSP00000406881
ENST00000556825 ENSP00000451169
ENST00000557740
ENST00000554600
ENST00000553324
ENST00000554467
ENST00000557487 ENSP00000452315
ENST00000553950
ENST00000555634 ENSP00000450930
ENST00000556689 ENSP00000452035
ENST00000557269 ENSP00000450594
ENST00000555563 ENSP00000451630
ENST00000557433 ENSP00000450610
ENST00000557348 ENSP00000450927
ENST00000557703 ENSP00000450452
ENST00000553529 ENSP00000452161
ENST00000554310 ENSP00000450893
ENST00000557302
ENST00000554656
ENST00000557427 ENSP00000452045
ENST00000553474 ENSP00000452419
ENST00000555773 ENSP00000451968
ENST00000554975 ENSP00000452404
ENST00000555774 ENSP00000451872
ENST00000555116 ENSP00000452339
ENST00000553837 ENSP00000451371
ENST00000554604 ENSP00000452163
ENST00000553949
ENST00000556737 ENSP00000451495
ENST00000553868
ENST00000555213
ENST00000557529 ENSP00000450490
ENST00000556798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004372 glycine hydroxymethyltransferase activity
GO:0008732 L-allo-threonine aldolase activity
GO:0016597 amino acid binding
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
Biological Process
GO:0006544 glycine metabolic process
GO:0006545 glycine biosynthetic process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0019264 glycine biosynthetic process from serine
GO:0035999 tetrahydrofolate interconversion
GO:0051289 protein homotetramerization
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0015630 microtubule cytoskeleton
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025403
View Gene Order
ENSBTAG00000031500
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00670
One carbon pool by folate pathway
hsa00460
Cyanoamino acid metabolism pathway
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
INOH website
Folate metabolism pathway
INOH website
Glycine Serine metabolism pathway
INOH website
Lysine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL G3V241 G3V3Y8 G3V4T0 G3V4X0
UniProt Splice Variant
Entrez Gene 6472
UniGene Hs.741179
RefSeq NM_001166356 NM_001166357 NM_001166358 NM_001166359 NM_005412
HUGO HGNC:10852
OMIM 138450
CCDS CCDS53805 CCDS55837 CCDS8934
HPRD 00717
IMGT
EMBL AC137834
GenPept
RNA Seq Atlas 6472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca