Version 5.4
Mus musculus Gene: Osgin1
Summary
InnateDB Gene IDBG-195341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Osgin1
Gene Name oxidative stress induced growth inhibitor 1
Synonyms 1700012B18Rik; Okl38
Species Mus musculus
Ensembl Gene ENSMUSG00000074063
Encoded Proteins
IDBP-195343
oxidative stress induced growth inhibitor 1
IDBP-535719
oxidative stress induced growth inhibitor 1
IDBP-539235
oxidative stress induced growth inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140961:
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:119434124-119446256
Strand Forward strand
Band E1
Transcripts
ENSMUST00000098365 ENSMUSP00000095968
ENSMUST00000131448 ENSMUSP00000120477
ENSMUST00000152420 ENSMUSP00000114467
ENSMUST00000126414
ENSMUST00000145604
ENSMUST00000144381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0030308 negative regulation of cell growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140961
View Gene Order
ENSBTAG00000012508
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_027950 XM_006531377 XM_006531378 XM_006531379 XM_006531380 XM_006531381
OMIM
CCDS CCDS22704
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca