Version 5.4
Homo sapiens Gene: OSGIN1
Summary
InnateDB Gene IDBG-43985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSGIN1
Gene Name oxidative stress induced growth inhibitor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140961
Encoded Proteins
IDBP-43987
oxidative stress induced growth inhibitor 1
IDBP-43989
oxidative stress induced growth inhibitor 1
IDBP-243900
oxidative stress induced growth inhibitor 1
IDBP-754301
IDBP-749671
IDBP-747096
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:83948282-83966332
Strand Forward strand
Band q23.3
Transcripts
ENST00000343939 ENSP00000343376
ENST00000361711 ENSP00000355374
ENST00000393306 ENSP00000376983
ENST00000563543
ENST00000567707 ENSP00000457157
ENST00000565123 ENSP00000462048
ENST00000561552 ENSP00000456965
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074063
View Gene Order
ENSBTAG00000012508
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.128055
RefSeq NM_182981
HUGO
OMIM
CCDS CCDS10939
HPRD 06412
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca