InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddx11

Summary

InnateDB Gene

IDBG-195415.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx11

Gene Name

DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035842

Encoded Proteins

IDBP-627262

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000013573:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:66123520-66152167

Strand

Forward strand

Band

E1.1

Transcripts

ENSMUST00000163605

ENSMUSP00000130440

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0007062	sister chromatid cohesion
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0000790	nuclear chromatin
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0030496	midbody

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000013573

View Gene Order

ENSBTAG00000007093

Not yet available

Pathways

NETPATH

REACTOME

REACT_239697

Unfolded Protein Response (UPR) pathway

REACT_247926

Metabolism of proteins pathway

REACT_231085

IRE1alpha activates chaperones pathway

REACT_106572

XBP1(S) activates chaperone genes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18273

XBP1(S) activates chaperone genes pathway

REACT_18368

IRE1alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q6AXC6

TrEMBL

UniProt Splice Variant

Entrez Gene

320209

UniGene

RefSeq

NM_001003919

OMIM

CCDS

CCDS28945

HPRD

IMGT

MGI ID

MGI:2443590

MGI Symbol

Ddx11

EMBL

BC079656

GenPept

AAH79656

RNA Seq Atlas

320209