Version 5.4
Homo sapiens Gene: DDX11
Summary
InnateDB Gene IDBG-25634.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX11
Gene Name DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Synonyms CHL1; CHLR1; KRG2; WABS
Species Homo sapiens
Ensembl Gene ENSG00000013573
Encoded Proteins
IDBP-25640
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-25642
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-366586
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-371288
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-371291
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-601723
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-598725
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-591648
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-589473
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-596174
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-595369
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-602430
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-598188
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-810963
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
IDBP-597753
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-583408
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
IDBP-593594
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:31073845-31104791
Strand Forward strand
Band p11.21
Transcripts
ENST00000228264 ENSP00000228264
ENST00000350437 ENSP00000309965
ENST00000435753 ENSP00000406799
ENST00000438391 ENSP00000407646
ENST00000415475 ENSP00000406457
ENST00000542838 ENSP00000443426
ENST00000542129 ENSP00000442466
ENST00000540935 ENSP00000443578
ENST00000539049 ENSP00000445568
ENST00000536265
ENST00000545668 ENSP00000440402
ENST00000535158
ENST00000543756 ENSP00000439298
ENST00000542244 ENSP00000441425
ENST00000535317 ENSP00000440171
ENST00000544652 ENSP00000473610
ENST00000538345 ENSP00000445219
ENST00000542242
ENST00000543026
ENST00000545717
ENST00000536580
ENST00000539673
ENST00000543511
ENST00000539699
ENST00000542661
ENST00000538740
ENST00000542777
ENST00000537136
ENST00000545115 ENSP00000443750
ENST00000539702 ENSP00000441015
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008094 DNA-dependent ATPase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000084 mitotic S phase
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006139 nucleobase-containing compound metabolic process
GO:0006200 ATP catabolic process
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007062 sister chromatid cohesion
GO:0008152 metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0016032 viral process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032508 DNA duplex unwinding
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035842
View Gene Order
ENSBTAG00000007093
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443960
RefSeq NM_001257144 NM_001257145 NM_004399 NM_030653 NM_152438 XM_005253331 XM_005253333 XM_006719044 XM_006719053
HUGO
OMIM
CCDS CCDS41767 CCDS44856 CCDS58224 CCDS8721
HPRD 03095
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca