InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mbtps1

Summary

InnateDB Gene

IDBG-195454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbtps1

Gene Name

membrane-bound transcription factor peptidase, site 1

Synonyms

0610038M03Rik; AV003995; mKIAA0091; S1P; SKI-1; Ski1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031835

Encoded Proteins

IDBP-195456

membrane-bound transcription factor peptidase, site 1

IDBP-195458

membrane-bound transcription factor peptidase, site 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140943:
The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq, Jul 2008]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:119508156-119558761

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098362	ENSMUSP00000095965
ENSMUST00000081381	ENSMUSP00000080117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006629	lipid metabolic process
GO:0007040	lysosome organization
GO:0008203	cholesterol metabolic process
GO:0042990	regulation of transcription factor import into nucleus

Cellular Component

GO:0000139	Golgi membrane
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016021	integral component of membrane