InnateDB Protein
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IDBP-195456.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mbtps1
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Protein Name
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membrane-bound transcription factor peptidase, site 1
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Synonyms
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0610038M03Rik; AV003995; mKIAA0091; S1P; SKI-1; Ski1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000095965
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InnateDB Gene
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IDBG-195454 (Mbtps1)
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Protein Structure
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Function |
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=May sort to other organelles, including lysosomal and/or endosomal compartments. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927235
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InterPro |
IPR000209
Peptidase S8/S53 domain
IPR015500
Peptidase S8, subtilisin-related
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PFAM |
PF00082
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PRINTS |
PR00723
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WTZ2
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PhosphoSite |
PhosphoSite-Q9WTZ2
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TrEMBL |
Q3TP75
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UniProt Splice Variant |
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Entrez Gene |
56453
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UniGene |
Mm.444427
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RefSeq |
NP_062683
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MGI ID |
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MGI Symbol |
Mbtps1
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OMIM |
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CCDS |
CCDS22707
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HPRD |
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IMGT |
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EMBL |
AF094820
AK029048
AK164654
BC054837
BC057198
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GenPept |
AAD27010
AAH54837
AAH57198
BAC26263
BAE37862
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