Version 5.4
Mus musculus Gene: Nab2
Summary
InnateDB Gene IDBG-195715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nab2
Gene Name Ngfi-A binding protein 2
Synonyms AI451907
Species Mus musculus
Ensembl Gene ENSMUSG00000025402
Encoded Proteins
IDBP-195717
Ngfi-A binding protein 2
IDBP-195719
Ngfi-A binding protein 2
IDBP-531964
Ngfi-A binding protein 2
IDBP-537369
Ngfi-A binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166886:
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:127660918-127668568
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000026469 ENSMUSP00000026469
ENSMUST00000099157 ENSMUSP00000096761
ENSMUST00000128780 ENSMUSP00000121737
ENSMUST00000129252 ENSMUSP00000118036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008134 transcription factor binding
Biological Process
GO:0001958 endochondral ossification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0014037 Schwann cell differentiation
GO:0016480 negative regulation of transcription from RNA polymerase III promoter
GO:0042552 myelination
GO:0045682 regulation of epidermis development
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166886
View Gene Order
ENSBTAG00000006324
Not yet available
Cross-References
SwissProt
TrEMBL D3Z008
UniProt Splice Variant
Entrez Gene 17937
UniGene Mm.336898
RefSeq NM_001122895 NM_008668 XM_006513330 XM_006513331
OMIM
CCDS CCDS24247 CCDS48719
HPRD
IMGT
MGI ID MGI:107563
MGI Symbol Nab2
EMBL AC160970
GenPept
RNA Seq Atlas 17937

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca