InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nab2

Summary

InnateDB Protein

IDBP-195717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nab2

Protein Name

Ngfi-A binding protein 2

Synonyms

AI451907;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026469

InnateDB Gene

IDBG-195715 (Nab2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.

Subcellular Localization

Nucleus. Note=Isoform 2 is not localized to the nucleus.

Disease Associations

Tissue Specificity

Highly expressed in brain and thymus, and at lower levels in spleen, kidney, heart and testis. Isoform 1 is predominantly expressed in testis, whereas isoform 3 is more abundant in thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008134	transcription factor binding

Biological Process

GO:0001958	endochondral ossification
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0014037	Schwann cell differentiation
GO:0016480	negative regulation of transcription from RNA polymerase III promoter
GO:0042552	myelination
GO:0045682	regulation of epidermis development
GO:0045892	negative regulation of transcription, DNA-templated