Version 5.4
Mus musculus Gene: Ppp3ca
Summary
InnateDB Gene IDBG-195763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp3ca
Gene Name protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms 2900074D19Rik; Caln; Calna; CN; CnA
Species Mus musculus
Ensembl Gene ENSMUSG00000028161
Encoded Proteins
IDBP-195765
protein phosphatase 3, catalytic subunit, alpha isoform
IDBP-195769
protein phosphatase 3, catalytic subunit, alpha isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17965024
[Homo sapiens] PPP3CA (calcineurin) is a serine/threonine phosphatase that is activated by calcium and calmodulin that promotes HIF1A expression by dephosphorylating RACK1 and blocking RACK1 dimerization.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138814:
Gene Information
Type Protein coding
Genomic Location Chromosome 3:136670124-136937727
Strand Forward strand
Band G3
Transcripts
ENSMUST00000056758 ENSMUSP00000053101
ENSMUST00000070198 ENSMUSP00000071040
ENSMUST00000124206
ENSMUST00000124777
ENSMUST00000130768
ENSMUST00000130114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008144 drug binding
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001975 response to amphetamine
GO:0006470 protein dephosphorylation
GO:0006606 protein import into nucleus
GO:0006816 calcium ion transport
GO:0014883 transition between fast and slow fiber
GO:0016311 dephosphorylation
GO:0019722 calcium-mediated signaling
GO:0033173 calcineurin-NFAT signaling cascade
GO:0033555 multicellular organismal response to stress
GO:0035690 cellular response to drug
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046676 negative regulation of insulin secretion
GO:0048741 skeletal muscle fiber development
GO:0050804 regulation of synaptic transmission
GO:0051592 response to calcium ion
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005955 calcineurin complex
GO:0016020 membrane
GO:0030018 Z disc
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138814
View Gene Order
ENSBTAG00000016005
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_203795
DARPP-32 events pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_230745
Immune System pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_221970
Ca2+ pathway pathway
REACT_188202
FCERI mediated Ca+2 mobilization pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04360
Axon guidance pathway
mmu04370
VEGF signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04210
Apoptosis pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04114
Oocyte meiosis pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_15
IL3 pathway
REACTOME
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_212636
Signaling by Wnt pathway
REACT_205369
Signaling by GPCR pathway
REACT_205490
DARPP-32 events pathway
REACT_213138
Immune System pathway
REACT_216829
FCERI mediated Ca+2 mobilization pathway
REACT_209727
Ca2+ pathway pathway
REACT_214353
Signal Transduction pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_219672
Opioid Signalling pathway
REACT_216714
Innate Immune System pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04114
Oocyte meiosis pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
bcr_5pathway
BCR signaling pathway
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt P63328
TrEMBL B2RRX2
UniProt Splice Variant
Entrez Gene 19055
UniGene Mm.331389
RefSeq NM_008913 XM_006501136
OMIM
CCDS CCDS17860
HPRD
IMGT
MGI ID MGI:107164
MGI Symbol Ppp3ca
EMBL AK146387 AK150393 BC138612 CH466532 J04134 J05479 S78668
GenPept AAA37359 AAA37432 AAB34675 AAI38613 BAE27131 BAE29521 EDL12129
RNA Seq Atlas 19055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca