InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP3CA

Summary

InnateDB Gene

IDBG-31818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP3CA

Gene Name

protein phosphatase 3, catalytic subunit, alpha isozyme

Synonyms

CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B

Species

Homo sapiens

Ensembl Gene

ENSG00000138814

Encoded Proteins

IDBP-31820

protein phosphatase 3, catalytic subunit, alpha isozyme

IDBP-240741

protein phosphatase 3, catalytic subunit, alpha isozyme

IDBP-240743

protein phosphatase 3, catalytic subunit, alpha isozyme

IDBP-481743

protein phosphatase 3, catalytic subunit, alpha isozyme

IDBP-477985

protein phosphatase 3, catalytic subunit, alpha isozyme

IDBP-480601

protein phosphatase 3, catalytic subunit, alpha isozyme

IDBP-594756

protein phosphatase 3, catalytic subunit, alpha isozyme

IDBP-595180

protein phosphatase 3, catalytic subunit, alpha isozyme

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17965024

PPP3CA (calcineurin) is a serine/threonine phosphatase that is activated by calcium and calmodulin that promotes HIF1A expression by dephosphorylating RACK1 and blocking RACK1 dimerization.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:101023409-101348278

Strand

Reverse strand

Band

q24

Transcripts

ENST00000323055	ENSP00000320580
ENST00000394854	ENSP00000378323
ENST00000394853	ENSP00000378322
ENST00000512215	ENSP00000422781
ENST00000507176	ENSP00000422990
ENST00000492351	ENSP00000426565
ENST00000510292
ENST00000529324	ENSP00000431619
ENST00000525819	ENSP00000434599

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	64 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008144	drug binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001975	response to amphetamine
GO:0006470	protein dephosphorylation
GO:0006606	protein import into nucleus
GO:0006816	calcium ion transport
GO:0014883	transition between fast and slow fiber
GO:0016311	dephosphorylation
GO:0019722	calcium-mediated signaling
GO:0033173	calcineurin-NFAT signaling cascade
GO:0033555	multicellular organismal response to stress
GO:0035690	cellular response to drug
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042110	T cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046676	negative regulation of insulin secretion
GO:0048741	skeletal muscle fiber development
GO:0050804	regulation of synaptic transmission
GO:0051592	response to calcium ion
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005955	calcineurin complex
GO:0016020	membrane
GO:0030018	Z disc
GO:0042383	sarcolemma