InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptprc

Summary

InnateDB Gene

IDBG-195821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprc

Gene Name

protein tyrosine phosphatase, receptor type, C

Synonyms

B220; Cd45; CD45R; L-CA; loc; Ly-5; Lyt-4; T200

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026395

Encoded Proteins

IDBP-788489

protein tyrosine phosphatase, receptor type, C

IDBP-788490

protein tyrosine phosphatase, receptor type, C

IDBP-788491

protein tyrosine phosphatase, receptor type, C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 11201744

[Homo sapiens] PTPRC (CD45) suppresses JAK (Janus kinase) kinases and negatively regulates cytokine receptor signaling by regulating interleukin-3-mediated cellular proliferation, erythropoietin-dependent haematopoiesis and antiviral responses in vitro and in vivo.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081237:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:138063407-138175706

Strand

Reverse strand

Band

Transcripts

ENSMUST00000112036
ENSMUST00000182755	ENSMUSP00000138275
ENSMUST00000182283	ENSMUSP00000138800
ENSMUST00000183301	ENSMUSP00000138350
ENSMUST00000188596
ENSMUST00000187586
ENSMUST00000183262
ENSMUST00000182138
ENSMUST00000183229
ENSMUST00000185570
ENSMUST00000186628

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002378	immunoglobulin biosynthetic process
GO:0002711	positive regulation of T cell mediated immunity
GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159	leukocyte cell-cell adhesion
GO:0010332	response to gamma radiation
GO:0016311	dephosphorylation
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0031953	negative regulation of protein autophosphorylation
GO:0034113	heterotypic cell-cell adhesion
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042098	T cell proliferation
GO:0042100	B cell proliferation
GO:0042102	positive regulation of T cell proliferation
GO:0043410	positive regulation of MAPK cascade
GO:0044770	cell cycle phase transition
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045577	regulation of B cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0048539	bone marrow development
GO:0048864	stem cell development
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0050855	regulation of B cell receptor signaling pathway
GO:0050857	positive regulation of antigen receptor-mediated signaling pathway
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:2000473	positive regulation of hematopoietic stem cell migration
GO:2000648	positive regulation of stem cell proliferation
GO:2001236	regulation of extrinsic apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery