InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dtx1

Summary

InnateDB Gene

IDBG-196224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dtx1

Gene Name

deltex 1 homolog (Drosophila)

Synonyms

Fxit1; mKIAA4160

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029603

Encoded Proteins

IDBP-196226

deltex 1 homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135144:
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:120680202-120711927

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031607	ENSMUSP00000031607
ENSMUST00000145174
ENSMUST00000144889
ENSMUST00000151562
ENSMUST00000124079

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0017124	SH3 domain binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0008593	regulation of Notch signaling pathway
GO:0010001	glial cell differentiation
GO:0016567	protein ubiquitination
GO:0045581	negative regulation of T cell differentiation
GO:0045665	negative regulation of neuron differentiation