InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DTX1

Summary

InnateDB Gene

IDBG-58410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DTX1

Gene Name

deltex homolog 1 (Drosophila)

Synonyms

hDx-1

Species

Homo sapiens

Ensembl Gene

ENSG00000135144

Encoded Proteins

IDBP-58412

deltex homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:113056709-113098028

Strand

Forward strand

Band

q24.13

Transcripts

ENST00000257600	ENSP00000257600
ENST00000548759
ENST00000547974
ENST00000553140
ENST00000547730

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005112	Notch binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0017124	SH3 domain binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008593	regulation of Notch signaling pathway
GO:0010001	glial cell differentiation
GO:0016567	protein ubiquitination
GO:0045581	negative regulation of T cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:2001141	regulation of RNA biosynthetic process