Version 5.4
Mus musculus Gene: Crb1
Summary
InnateDB Gene IDBG-196274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crb1
Gene Name crumbs homolog 1 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000063681
Encoded Proteins
IDBP-196276
crumbs homolog 1 (Drosophila)
IDBP-532874
crumbs homolog 1 (Drosophila)
IDBP-532495
crumbs homolog 1 (Drosophila)
IDBP-535089
crumbs homolog 1 (Drosophila)
IDBP-540655
crumbs homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134376:
This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:139197056-139377100
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000059825 ENSMUSP00000060769
ENSMUST00000131586 ENSMUSP00000120391
ENSMUST00000145244 ENSMUSP00000118324
ENSMUST00000123065
ENSMUST00000133765
ENSMUST00000136062
ENSMUST00000132845 ENSMUSP00000123136
ENSMUST00000137030 ENSMUSP00000121396
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007009 plasma membrane organization
GO:0042462 eye photoreceptor cell development
GO:0061024 membrane organization
Cellular Component
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134376
View Gene Order
ENSBTAG00000008944
Not yet available
Cross-References
SwissProt
TrEMBL B7ZC61 Q7TSG9 Q8K0H9
UniProt Splice Variant
Entrez Gene 170788
UniGene Mm.95700
RefSeq NM_133239 XM_006529218 XM_006529219 XM_006529220 XM_006529221 XM_006529222 XM_006529223 XM_006529224
OMIM
CCDS CCDS15336
HPRD
IMGT
MGI ID MGI:2136343
MGI Symbol Crb1
EMBL AC116810 AC138741 AL606536 BC031378 BC053331
GenPept AAH31378 AAH53331
RNA Seq Atlas 170788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca