Version 5.4
Bos taurus Gene: CRB1
Summary
InnateDB Gene IDBG-638614.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRB1
Gene Name crumbs homolog 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008944
Encoded Proteins
IDBP-690699
crumbs homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134376:
This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:78094758-78320235
Strand Forward strand
Band
Transcripts
ENSBTAT00000033880 ENSBTAP00000033786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007009 plasma membrane organization
GO:0042462 eye photoreceptor cell development
GO:0061024 membrane organization
Cellular Component
GO:0005886 plasma membrane
GO:0005902 microvillus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134376
View Gene Order
ENSMUSG00000063681
View Gene Order
Cross-References
SwissProt
TrEMBL F1N3A5
UniProt Splice Variant
Entrez Gene 520406
UniGene Bt.62177
RefSeq NM_001192482
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043890 DAAA02043891 DAAA02043892 DAAA02043893 DAAA02043894 DAAA02043895 DAAA02043896
GenPept
RNA Seq Atlas 520406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca