InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Oas3

Summary

InnateDB Gene

IDBG-196327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oas3

Gene Name

2'-5' oligoadenylate synthetase 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032661

Encoded Proteins

IDBP-196329

2'-5' oligoadenylate synthetase 3

IDBP-624893

2'-5' oligoadenylate synthetase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21190483

Oas3 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas3 activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.

InnateDB Annotation from Orthologs

Summary

PMID 21190483

[Homo sapiens] OAS3 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the OAS3 activates RNASEL to cleave ssRNA. The OAS/RNASEL pathway triggers the RIG-I pathway and induce IFNB production.

PMID 26063222

[Homo sapiens] Antiviral activity of the 2�?�,5�?�-oligoadenylate synthetase (OAS) gene variants against dengue virus shows strong and serotype-specific disparities.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111331:
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
This gene encodes an enzyme included in the 2\', 5\' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2\', 5\' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:120753098-120777661

Strand

Reverse strand

Band

Transcripts

ENSMUST00000044833	ENSMUSP00000035588
ENSMUST00000165820	ENSMUSP00000125873
ENSMUST00000166703

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001730	2'-5'-oligoadenylate synthetase activity
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006955	immune response
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060700	regulation of ribonuclease activity