InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adh1

Summary

InnateDB Gene

IDBG-196460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adh1

Gene Name

alcohol dehydrogenase 1 (class I)

Synonyms

Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e; AI194826

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074207

Encoded Proteins

IDBP-196462

alcohol dehydrogenase 1 (class I)

IDBP-535617

alcohol dehydrogenase 1 (class I)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196616:
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:138260991-138290698

Strand

Forward strand

Band

Transcripts

ENSMUST00000004232	ENSMUSP00000004232
ENSMUST00000162032
ENSMUST00000161799
ENSMUST00000159159	ENSMUSP00000124688

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006068	ethanol catabolic process
GO:0032526	response to retinoic acid
GO:0033574	response to testosterone
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0048149	behavioral response to ethanol
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process