InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adh1

Summary

InnateDB Protein

IDBP-196462.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adh1

Protein Name

alcohol dehydrogenase 1 (class I)

Synonyms

Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e; AI194826;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004232

InnateDB Gene

IDBG-196460 (Adh1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed at high levels in the liver, small intestine and eye, at moderate levels in kidney, ovary and uterus, and at low levels in the spinal cord, thymus, heart, stomach mucosa, skin and testis. {ECO:0000269PubMed:7738026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006068	ethanol catabolic process
GO:0032526	response to retinoic acid
GO:0033574	response to testosterone
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0048149	behavioral response to ethanol
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:87921

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00329