Version 5.4
Homo sapiens Gene: HDAC11
Summary
InnateDB Gene IDBG-19657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC11
Gene Name histone deacetylase 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163517
Encoded Proteins
IDBP-19661
histone deacetylase 11
IDBP-292723
histone deacetylase 11
IDBP-292724
histone deacetylase 11
IDBP-292721
histone deacetylase 11
IDBP-292726
histone deacetylase 11
IDBP-292728
histone deacetylase 11
IDBP-292730
histone deacetylase 11
IDBP-364992
histone deacetylase 11
IDBP-365012
histone deacetylase 11
IDBP-365036
histone deacetylase 11
IDBP-365044
histone deacetylase 11
IDBP-365047
histone deacetylase 11
IDBP-365049
histone deacetylase 11
IDBP-365052
histone deacetylase 11
IDBP-365055
histone deacetylase 11
IDBP-365057
histone deacetylase 11
IDBP-478495
histone deacetylase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23980205
MIR145 directly targets HDAC11 to promote IL10 expression in TLR4-triggered macrophages.
Entrez Gene
Summary This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:13479724-13506424
Strand Forward strand
Band p25.1
Transcripts
ENST00000295757 ENSP00000295757
ENST00000402259 ENSP00000384706
ENST00000402271 ENSP00000384123
ENST00000404040 ENSP00000385475
ENST00000404548 ENSP00000385528
ENST00000405025 ENSP00000384019
ENST00000405478 ENSP00000385252
ENST00000433119 ENSP00000412514
ENST00000425430 ENSP00000399792
ENST00000458642 ENSP00000405403
ENST00000418189 ENSP00000411792
ENST00000437379 ENSP00000395188
ENST00000434848 ENSP00000398651
ENST00000416248 ENSP00000402298
ENST00000455904 ENSP00000396122
ENST00000446613 ENSP00000401487
ENST00000475818
ENST00000522202 ENSP00000429794
ENST00000487585
ENST00000498532
ENST00000495099
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 135 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016787 hydrolase activity
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008152 metabolic process
GO:0014003 oligodendrocyte development
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0045087 innate immune response (InnateDB)
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034245
View Gene Order
ENSBTAG00000007208
Not yet available
Pathways
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
hdac_classii_pathway
Signaling events mediated by HDAC Class II
Cross-References
SwissProt
TrEMBL C9JMH0 Q658J9
UniProt Splice Variant
Entrez Gene 79885
UniGene Hs.404802 Hs.620910
RefSeq NM_001136041 NM_024827 XM_005265491
HUGO HGNC:19086
OMIM 607226
CCDS CCDS2615 CCDS46760
HPRD 09146
IMGT
EMBL AC027124 AL834223 CH471055
GenPept CAH56375 EAW64158
RNA Seq Atlas 79885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca