Version 5.4
Homo sapiens Protein: HDAC11
Summary
InnateDB Protein IDBP-19661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC11
Protein Name histone deacetylase 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295757
InnateDB Gene IDBG-19657 (HDAC11)
Protein Structure
UniProt Annotation
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. {ECO:0000269PubMed:11948178}.
Subcellular Localization Nucleus. Note=Predominantly nuclear.
Disease Associations
Tissue Specificity Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 135 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016787 hydrolase activity
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008152 metabolic process
GO:0014003 oligodendrocyte development
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0045087 innate immune response (InnateDB)
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000286 Histone deacetylase superfamily
IPR023801 Histone deacetylase domain
PFAM PF00850
PRINTS PR01270
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DB2
PhosphoSite PhosphoSite-Q96DB2
TrEMBL Q6IA14
UniProt Splice Variant
Entrez Gene 79885
UniGene Hs.620910
RefSeq NP_079103
HUGO HGNC:19086
OMIM 607226
CCDS CCDS2615
HPRD 09146
IMGT
EMBL AC027124 AK025426 AK025890 AK293223 AL137362 BC009676 CH471055 CR457341
GenPept AAH09676 BAB15127 BAB15272 BAG56762 CAB70712 CAG33622 EAW64165 EAW64168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca