Version 5.4
Mus musculus Gene: Foxc2
Summary
InnateDB Gene IDBG-196604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxc2
Gene Name forkhead box C2
Synonyms Fkh14; Hfhbf3; MFH-1; Mfh1
Species Mus musculus
Ensembl Gene ENSMUSG00000046714
Encoded Proteins
IDBP-196606
forkhead box C2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176692:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:121116171-121118895
Strand Forward strand
Band E1
Transcripts
ENSMUST00000054691 ENSMUSP00000055290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001568 blood vessel development
GO:0001569 patterning of blood vessels
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001756 somitogenesis
GO:0001822 kidney development
GO:0001945 lymph vessel development
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0003007 heart morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009725 response to hormone
GO:0010595 positive regulation of endothelial cell migration
GO:0014032 neural crest cell development
GO:0030199 collagen fibril organization
GO:0033625 positive regulation of integrin activation
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035050 embryonic heart tube development
GO:0035470 positive regulation of vascular wound healing
GO:0043010 camera-type eye development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046620 regulation of organ growth
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048341 paraxial mesoderm formation
GO:0048343 paraxial mesodermal cell fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048844 artery morphogenesis
GO:0050880 regulation of blood vessel size
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0072011 glomerular endothelium development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072144 glomerular mesangial cell development
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176692
View Gene Order
ENSBTAG00000012465
Not yet available
Cross-References
SwissProt Q61850
TrEMBL B9EI61
UniProt Splice Variant
Entrez Gene 14234
UniGene Mm.14092 Mm.402880
RefSeq NM_013519
OMIM
CCDS CCDS40499
HPRD
IMGT
MGI ID MGI:1347481
MGI Symbol Foxc2
EMBL AK076319 BC139208 CH466525 S63607 X74040 X92499 Y08222
GenPept AAB27463 AAI39209 BAC36298 CAA52192 CAA63244 CAA69399 EDL11653
RNA Seq Atlas 14234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca