InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxc2

Summary

InnateDB Protein

IDBP-196606.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxc2

Protein Name

forkhead box C2

Synonyms

Fkh14; Hfhbf3; MFH-1; Mfh1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055290

InnateDB Gene

IDBG-196604 (Foxc2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. {ECO:0000269PubMed:9169153}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001503	ossification
GO:0001568	blood vessel development
GO:0001569	patterning of blood vessels
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001756	somitogenesis
GO:0001822	kidney development
GO:0001945	lymph vessel development
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0003007	heart morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0007507	heart development
GO:0008283	cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0009725	response to hormone
GO:0010595	positive regulation of endothelial cell migration
GO:0014032	neural crest cell development
GO:0030199	collagen fibril organization
GO:0033625	positive regulation of integrin activation
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035050	embryonic heart tube development
GO:0035470	positive regulation of vascular wound healing
GO:0043010	camera-type eye development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046620	regulation of organ growth
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048341	paraxial mesoderm formation
GO:0048343	paraxial mesodermal cell fate commitment
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048844	artery morphogenesis
GO:0050880	regulation of blood vessel size
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060038	cardiac muscle cell proliferation
GO:0072011	glomerular endothelium development
GO:0072112	glomerular visceral epithelial cell differentiation
GO:0072144	glomerular mesangial cell development
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
GO:1902257	negative regulation of apoptotic process involved in outflow tract morphogenesis