Version 5.4
Mus musculus Gene: Oas1a
Summary
InnateDB Gene IDBG-196676.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oas1a
Gene Name 2'-5' oligoadenylate synthetase 1A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000052776
Encoded Proteins
IDBP-196678
2'-5' oligoadenylate synthetase 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21190483
Oas1a is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas1a activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:120896256-120907521
Strand Reverse strand
Band F
Transcripts
ENSMUST00000080322 ENSMUSP00000079198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001730 2'-5'-oligoadenylate synthetase activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006955 immune response
GO:0009615 response to virus
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
KEGG
mmu05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt P11928
TrEMBL
UniProt Splice Variant
Entrez Gene 246730
UniGene Mm.14301 Mm.416051
RefSeq NM_145211
OMIM
CCDS CCDS19630
HPRD
IMGT
MGI ID MGI:2180860
MGI Symbol Oas1a
EMBL AC015535 AK149613 BC013715 BC057878 CH466529 M33863 X04958 X58077
GenPept AAA37116 AAH13715 AAH57878 BAE28990 CAA28620 CAA41105 EDL19743
RNA Seq Atlas 246730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca