InnateDB Protein
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IDBP-196678.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Oas1a
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Protein Name
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2'-5' oligoadenylate synthetase 1A
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000079198
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InnateDB Gene
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IDBG-196676 (Oas1a)
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Protein Structure
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Function |
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269PubMed:12396720}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in the digestive tract and lymphoid organs. {ECO:0000269PubMed:12396720}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2180860
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InterPro |
IPR002934
Nucleotidyl transferase domain
IPR006116
2-5-oligoadenylate synthetase, N-terminal
IPR018952
2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal
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PFAM |
PF01909
PF10421
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P11928
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
246730
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UniGene |
Mm.416051
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RefSeq |
NP_660212
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MGI ID |
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MGI Symbol |
Oas1a
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OMIM |
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CCDS |
CCDS19630
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HPRD |
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IMGT |
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EMBL |
AC015535
AK149613
BC013715
BC057878
CH466529
M33863
X04958
X58077
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GenPept |
AAA37116
AAH13715
AAH57878
BAE28990
CAA28620
CAA41105
EDL19743
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