Version 5.4
Mus musculus Gene: Mip
Summary
InnateDB Gene IDBG-196885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mip
Gene Name major intrinsic protein of eye lens fiber
Synonyms Aqp0; Cat; Hfi; Lop; MIP26; shrivelled; Svl
Species Mus musculus
Ensembl Gene ENSMUSG00000025389
Encoded Proteins
IDBP-196887
major intrinsic protein of eye lens fiber
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135517:
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128225838-128231812
Strand Forward strand
Band D3
Transcripts
ENSMUST00000026455 ENSMUSP00000026455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015250 water channel activity
GO:0015267 channel activity
Biological Process
GO:0002088 lens development in camera-type eye
GO:0006810 transport
GO:0006833 water transport
GO:0007154 cell communication
GO:0007601 visual perception
GO:0015722 canalicular bile acid transport
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0046691 intracellular canaliculus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135517
View Gene Order
ENSBTAG00000010127
Not yet available
Pathways
NETPATH
REACTOME
REACT_226335
Aquaporin-mediated transport pathway
REACT_259079
Passive transport by Aquaporins pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23826
Passive transport by Aquaporins pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_216552
Aquaporin-mediated transport pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_208085
Passive transport by Aquaporins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P51180
TrEMBL
UniProt Splice Variant
Entrez Gene 17339
UniGene Mm.31625
RefSeq NM_008600
OMIM
CCDS CCDS24265
HPRD
IMGT
MGI ID MGI:96990
MGI Symbol Mip
EMBL AF000143 AK053490 AK053494 AK136287 U27502
GenPept AAC03168 AAC52416 BAC35401 BAC35402 BAE22916
RNA Seq Atlas 17339

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca