Version 5.4
Homo sapiens Gene: MIP
Summary
InnateDB Gene IDBG-41086.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIP
Gene Name major intrinsic protein of lens fiber
Synonyms AQP0; CTRCT15; LIM1; MIP26; MP26
Species Homo sapiens
Ensembl Gene ENSG00000135517
Encoded Proteins
IDBP-41088
major intrinsic protein of lens fiber
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56449502-56469166
Strand Reverse strand
Band q13.3
Transcripts
ENST00000257979 ENSP00000257979
ENST00000555551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015250 water channel activity
Biological Process
GO:0002088 lens development in camera-type eye
GO:0006810 transport
GO:0006833 water transport
GO:0007601 visual perception
GO:0015722 canalicular bile acid transport
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0046691 intracellular canaliculus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025389
View Gene Order
ENSBTAG00000010127
Not yet available
Pathways
NETPATH
REACTOME
REACT_23826
Passive transport by Aquaporins pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23887
Aquaporin-mediated transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P30301
TrEMBL
UniProt Splice Variant
Entrez Gene 4284
UniGene Hs.574026
RefSeq NM_012064
HUGO HGNC:7103
OMIM 154050
CCDS CCDS8919
HPRD 01098
IMGT
EMBL AC024884 BC074913 BC117474 U36308
GenPept AAC02794 AAH74913 AAI17475
RNA Seq Atlas 4284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca