InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Timeless

Summary

InnateDB Gene

IDBG-196902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timeless

Gene Name

timeless homolog (Drosophila)

Synonyms

C77407; Debt69; tim

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039994

Encoded Proteins

IDBP-196904

timeless homolog (Drosophila)

IDBP-271290

timeless homolog (Drosophila)

IDBP-271292

timeless homolog (Drosophila)

IDBP-271294

timeless homolog (Drosophila)

IDBP-271296

timeless homolog (Drosophila)

IDBP-620613

timeless homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128232065-128252941

Strand

Forward strand

Band

Transcripts

ENSMUST00000055539	ENSMUSP00000058021
ENSMUST00000105245	ENSMUSP00000100879
ENSMUST00000105244	ENSMUSP00000100878
ENSMUST00000105243	ENSMUSP00000100877
ENSMUST00000105242	ENSMUSP00000100876
ENSMUST00000105240
ENSMUST00000145710
ENSMUST00000125289	ENSMUSP00000132079
ENSMUST00000135538
ENSMUST00000135376
ENSMUST00000146945
ENSMUST00000142149
ENSMUST00000142484
ENSMUST00000136854
ENSMUST00000129147

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002009	morphogenesis of an epithelium
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007067	mitotic nuclear division
GO:0007623	circadian rhythm
GO:0030324	lung development
GO:0042752	regulation of circadian rhythm
GO:0044770	cell cycle phase transition
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048754	branching morphogenesis of an epithelial tube

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111602

View Gene Order

ENSBTAG00000020459

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

circadianpathway

Circadian rhythm pathway

atr_pathway

ATR signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.6458

RefSeq

NM_001136082 NM_001164080 NM_001164081 NM_011589 XM_006513580 XM_006513581 XM_006513582 XM_006513583

OMIM

CCDS

CCDS24266 CCDS48724 CCDS48725

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas